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Chapter
13
Diabetes
and Hypertension
Hypertension
(HTN) is twice as common in persons with diabetes compared to the general
population. For persons with diabetes, HTN contributes to the development
and progression of chronic complications, such as retinopathy, chronic
kidney disease and peripheral vascular disease. Achieving and maintaining
normal blood pressure levels can also minimize the risk of developing
these complications. Controlling HTN begins with detection and diagnosis.
Health care professionals are strongly encouraged to check blood pressure
at each visit. Following proper blood pressure monitoring technique
is essential to obtain accurate blood pressure readings.
Diagnosis,
Classification and Treatment of Blood Pressure
Blood
Pressure
Classification |
Systolic
Diastoic
mmHg |
No
Risk Factors*, No TCD/CCD** |
At least
one risk factor (not DM) No TOD/CCD** |
TOD/CCD**
and/or diabetes (with or without risk factors) |
| Normal |
< 120 and
< 80 |
Lifestyle Changes
|
Lifestyle Changes
|
Lifestyle Changes
|
| Prehypertension |
120–139
or 80–89 |
Lifestyle Changes
(up to 12 months) |
Lifestyle Changes
(up to 6 months)
|
Lifestyle Changes
+
Drug Therapy (if SBP > 130 and DBP > 80) |
Stage
1 Hypertension
|
140–159
or 90–99 |
Lifestyle Changes
+ Drug Therapy |
Lifestyle Changes
+ Drug Therapy
|
Lifestyle Changes
+ Drug Therapy |
| Stage
2 & 3 Hypertension |
> 160 or
> 100 |
Lifestyle Changes
+ Drug Therapy
|
Lifestyle Changes
+ Drug Therapy
|
Lifestyle Changes
+ Drug Therapy |
If systolic and diastolic
BP fall into two separate categories, use the higher category status.
*Cardiovascular
Risk Factors = hypertension, cigarette smoking, obesity (BMI
> 30), physical inactivity, dyslipidemia, diabetes, microalbuminuria,
age (over 55 for men; over 65 for women), family history of premature
cardiovascular disease (men under age 55 or women under age 65).
**TOD/CCD
= Target Organ Damage and Clinical Cardiovascular Disease. TOD includes
left ventricular hypertrophy, angina, prior myocardial infarction, prior
coronary revascularization, heart failure, stroke or transient ischemic
attack, chronic kidney disease, peripheral arterial disease or retinopathy.
According to the Joint
National Committee on Prevention, Detection, Evaluation and Treatment
of High Blood Pressure (JNC 7) and the American Diabetes Association,
the goal of treating hypertension is to achieve and maintain blood pressure
less than 130/80 mmHg for persons with diabetes
or chronic kidney disease.
Most persons with
high blood pressure, especially those over age 50, will reach their diastolic
BP goal when the systolic BP is at goal. Therefore, the primary focus
of therapy should be to achieve the systolic BP goal.
Nonpharmacological
Treatment
| Modification |
Recommendation |
Average
SBP Reduction |
| Weight
Reduction |
Maintain normal
body weight:
Body Mass Index (BMI) of 18.5-24.9 |
5-20 mmHg per
10 kg weight loss |
| DASH
Eating Plan |
Adopt a diet
rich in fruits, vegetables and low-fat dairy products with reduced
total & saturated fat.
See DASH handout at end of guideline. |
8-14 mmHg |
| Dietary
Sodium Restriction |
Reduce daily
sodium to less than 2400 mg.
Eat more fresh, unsalted foods
Use herbs and spices to season foods
Choose foods with <5% Daily Value for sodium
|
2-8 mmHg |
| Physical
Activity |
Regular aerobic
physical activity (brisk walking) at least 30 minutes per day most
days of the week. |
4-9 mmHg |
| Moderation of
Alcohol Consumption |
Limit alcohol
intake to 2 drinks per day (men) or 1 drink per day (women)
1 drink = 12 oz beer, 5 oz wine and 1½ oz liquor |
2-4 mmHg |
Pharmacological
Treatment
More than 2/3 of those with diabetes and HTN will require two or more
different medications to achieve the goal BP of less than 130/80 mmHg.
See below for evidence-based recommendations for the pharmacological treatment
of diabetes and HTN.
| Condition |
Recommended
drug therapy |
| Type
1 or 2 diabetes with NO cardiovascular risk factors or proteinuria |
ACE
inhibitor or ARB
Thiazide Diuretic (shown to reduce risk of stroke and cardiovascular
events) |
| Type
1 diabetes with any degree of albuminuria |
ACE
inhibitor (shown to delay the progression of nephroathy) |
| Type
2 diabetes and microalbuminuria |
ACE
inhibitor or ARB (shown to delay the progression to macroalbuminuria) |
|
Type 2 diabetes and macroalbuminuria, nephropathy or renal insufficiency |
ARB
should be strongly considered |
| Those
over age 55 with cardiovascular risk factors (history of cardiovascular
disease, smoking, dyslipidemia, overweight) |
ACE Inhibitor should be considered (to reduce the
risk of cardiovascular events) |
| Those
with recent myocardial infarction (MI) |
Beta
blocker should be added to current treatment (to reduce mortality) |
|
Those with microalbuminuria or overt nephropathy in which ACE Inhibitors
or ARBs are not tolerated |
Non-Dihydropyridine Calcium-Channel Blocker should
be considered. |
Commonly Used Oral Antihypertensive Medications
| Class |
Drug
(Trade Name) |
| Thiazide
Diuretics |
hydrochlorothiazide
(Microzide, HydroDIURIL)
indapamide (Lozol) |
| ACE Inhibitors |
benazepril (Lotensin)
enalapril (Vasotec)
fosinopril (Monopril)
|
lisinopril (Prinivil,
Zestril)
quinapril (Accupril)
ramipril (Altace) |
| ARBs |
candesartan (Atacand)
irbesartan (Avapro)
|
losartan (Cozaar)
valsartan (Diovan) |
| Beta
Blockers |
atenolol (Tenormin)
nadolol (Corgard)
|
metoprolol (Lopressor)
metoprolol extended release (Toprol XL) |
| Dihydropyridine
Calcium-Channel Blockers |
amlodipine (Norvasc)
felodipine (Plendil) |
nifedipine long-acting
(Adalat CC, Procardia XL) |
| Non-dihydropyridine
Calcium-Channel Blockers |
Diltiazem
extended release (Cardizem CD, Dilacor XR, Tiazac)
diltiazem extended release (Cardizem LA)
verapamil immediate release (Calan, Isoptin)
verapamil long acting (Calan SR, Isoptin SR)
verapamil (Coer, Covera HS, Verelan PM) |
| Alpha
1 Blockers |
doxazosin (Cardura)
prazosin (Minipress)
|
terazosin (Hytrin) |
Summary
The treatment of HTN involves considerable knowledge of the recommended
lifestyle changes and medications. Because high blood pressure is often
asymptomatic, lifestyle changes can be difficult to maintain. Since medications
may be expensive and may have unpleasant side effects, some stop treating
their high blood pressure with unfortunate results. Health care providers
should explore these issues and involve the physician, as needed, to help
persons with diabetes achieve their blood pressure goal. The keys are
to treat hypertension aggressively and to keep blood glucose under good
control to minimize the possibility of developing or exacerbating complications.
For
more information on Diabetes and Hypertension, check out the Diabetes
and Hypertension independent study module at www.diabetesinmichigan.org.
Click on independent study modules.
References:
The Seventh Report of the Joint National Committee on Prevention, Detection,
Evaluation and Treatment of High Blood Pressure, NIH Publication No. 03-5231,
National High Blood Pressure Education Program, May 2003.
American
Diabetes Association. Position Statement: Treatment of Hypertension in
Adults with Diabetes. Practical Diabetology, March 2003.
Wylie-Rosett
J. Hypertension and Diabetes: Clinical Synergy and Challenges. On the
Cutting Edge, 2004: Vol 25 (4): 4-8.
DASH
Eating Plan
| Food
Group |
Servings
based on (calories): |
Examples
Serving Sizes |
Comments |
| 1600 |
2000 |
3100 |
| Grains/Grain
products |
6
per day |
7-8
per day |
12-13
per day |
1 slice bread
½ - 1 cup ready-to-eat cereal
½ cup cooked rice, pasta, cereal |
Choose whole
grains. On the food label, look for whole wheat flour as first ingredient
and at least 2 grams fiber per serving. |
| Vegetables |
3–4
per day |
4–5
per day |
6
per day |
1 cup raw leafy
vegetables
½ cup cooked vegetable
6 oz vegetable juice |
Choose variety
of vegetables.
Rich sources of potassium, magnesium and fiber. |
| Fruits |
4
per day |
4
– 5 per day |
6
per day |
1 medium fruit
¼ cup dried fruit
½ cup fresh, frozen or canned fruit
4 oz fruit juice |
Choose variety
of fruits.
Good source of potassium, magnesium and fiber. |
| Low-fat or fat-free
dairy products |
2–3
per day |
2
– 3 per day |
3–4
per day |
8 oz 1%, ½
% or skim milk
6-8 oz yogurt
1 ½ oz cheese |
Major source
of calcium and protein.
Choose low-fat and fat-free dairy products. |
| Lean meats, poultry
and fish |
1-2
per day |
2
per day |
2-3
per day |
3 oz cooked lean
meat, skinless poultry or fish |
Choose lean and
trim away visible fats. Bake, boil, roast, broil versus frying |
| Nuts, seeds and
dried beans |
3
per week |
4–5
per week |
1
per day |
1/3 cup or 1½
oz nuts
1 Tbsp or ½ oz seeds
½ cup cooked dried beans
|
Rich source of
energy, magnesium, potassium, protein and fiber. |
| Fats and oils |
2
per day |
2
– 3 per day |
4
per day |
1 tsp soft tub
margarine
1 Tbsp low-fat mayonnaise
2 Tbsp light salad dressing
1 tsp vegetable oil |
High in calories.
Limit portions.
Limit saturated fats (solid at room
temperature).
Best oils: canola, olive |
| Sweets |
0 |
5
per week |
2
per day |
1 Tbsp sugar,
jam or jelly
½ oz jelly beans
8 oz lemonade |
Sweets should
be low in fat |
Source:
http://www.nhlbi.nih.gov/health/public/heart/hbp/dash/index.htm
How
to Lower Calories on the Dash Eating Plan
To
increase fruits
- Eat
a medium apple instead of 4 shortbread cookies (save 80 calories).
-
Eat ¼ cup dried fruit instead of a 2 oz bag of pork rinds (save
230 calories).
To increase
vegetables:
- Have a hamburger
that’s 3 oz meat instead of 6 oz. Add ½ cup of carrots
and ½ cup spinach. (save 200 calories)
- Instead of 5 oz
chicken, have a stir-fry with 2 oz chicken and 1½ cup raw vegetables.
Use a small amount of vegetable oil. (save 50 calories).
- Add fresh or frozen
vegetables to soups, pastas or rice.
To increase
low-fat or fat-free dairy products:
- Drink skim milk
instead of 2% milk (save 30 calories per cup) or whole milk (save 60
calories per cup).
- Have ½
cup low-fat frozen yogurt instead of 1½ oz chocolate bar (save
110 calories).
Other
calorie saving tips:
- Use
low-fat or fat-free condiments.
-
Use half the amount of regular vegetable oil, soft or liquid margarine
or salad dressing.
-
Eat smaller portions, cutting back gradually.
-
Check the food labels to compare fat content in packaged foods (low-fat
and fat-free does not always mean lower in calories).
-
Limit foods with lots of added sugar (pies, sweetened yogurts, candy
bars, ice cream, sherbet, regular soft drinks and fruit drinks)
-
Eat fruits canned in their own juice.
-
Snack on fruit, vegetable sticks or unbuttered, unsalted popcorn.
-
Drink water or club soda.
Tips
for reducing salt:
-
Eat more fresh, unsalted foods.
-
Avoid adding salt to homemade foods. Use spices for flavoring.
Read food labels and look for:
-
foods with < 5% of Daily Value for sodium
- snack
foods or salad dressings with < 200 mg of sodium per serving
-
sides (soups, rice, pasta, potatoes) with < 350 mg of sodium
per serving
-
frozen meals or fast foods with < 800 mg of sodium.
The
DASH (Dietary Approaches to Stop Hypertension) Study was a National Institutes
of Health research project. Following the DASH Eating Plan lowered blood
pressure levels in those with normal and elevated blood pressure levels
without reducing sodium or using drugs.
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